Cell migration is an adaptive process that depends on and responds to physical and molecular triggers. Moving cells sense and respond to tissue mechanics and induce transient or permanent tissue modifications, including extracellular matrix stiffening, compression and deformation, protein unfolding, proteolytic remodelling and jamming transitions. Here we discuss how the bi-directional relationship of cell-tissue interactions (mechanoreciprocity) allows cells to change position and contributes to single-cell and collective movement, structural and molecular tissue organization, and cell fate decisions.

中文翻译：

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细胞迁移的机械互易性。

细胞迁移是一种适应性过程，取决于物理和分子触发因素并对其做出响应。运动细胞感知并响应组织力学，并诱导瞬时或永久性组织修饰，包括细胞外基质变硬，压缩和变形，蛋白质解折叠，蛋白水解重塑和干扰转变。在这里，我们讨论细胞-组织相互作用的双向关系（机械互易性）如何使细胞改变位置并有助于单细胞和集体运动，结构和分子组织的组织以及细胞命运的决定。