Development of a controllable drug delivery system is imperative and important to reduce the side-effects and enhance the therapeutic efficacy of drugs. Metal–organic frameworks (MOFs) and nanoscale MOFs (NMOFs), as porous hybrids constructed by polydentate bridging ligands and metal-connecting nodes, have attracted significant attention from the scientific community due to their tailorable compositions and structures, excellent porosity, and easier surface modification. Significant progress has been achieved in the past decade, but most attempts still remain in the proof-of-concept stage. This review highlights the latest advances in NMOFs for drug delivery systems and classifies the current drug-loading method into three strategies according to the location of the cargos and cargo-carrier interactions: encapsulation strategy, direct assembly strategy, and post-synthesis strategy. Each feature and the latest advances in these strategies are highlighted. Finally, the challenges and future perspectives in this field have been discussed.

中文翻译：

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用于药物递送的纳米级金属有机框架：具有新希望的传统平台

开发可控的药物递送系统对于减少副作用和提高药物的治疗效果至关重要。金属有机骨架（MOF）和纳米级MOF（NMOF）作为由多齿桥接配体和金属连接节点构成的多孔杂化体，因其可定制的成分和结构，优异的孔隙率和更易加工的表面而引起了科学界的广泛关注。修改。在过去的十年中已经取得了重大进展，但是大多数尝试仍停留在概念验证阶段。这篇评论重点介绍了用于药物输送系统的NMOFs的最新进展，并根据货物的位置和货物与承运人之间的相互作用将当前的载药方法分为三种策略：封装策略，直接组装策略和后合成策略。这些策略的每个功能和最新进展都将突出显示。最后，讨论了该领域的挑战和未来前景。