Hydrolysis resistant functional polypeptide scaffold for biomaterials†,Polymer Chemistry

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Hydrolysis resistant functional polypeptide scaffold for biomaterials†
Polymer Chemistry ( IF 4.1 ) Pub Date : 2017-12-21 00:00:00 , DOI: 10.1039/c7py01586k
Wade Wang _{1,

2,

3,

4,

5} , Paula T. Hammond _{2,

3,

4,

5,

6}

Affiliation

For biomaterials, rich functionality often comes at a cost of precise control over structure. In this paper, we have developed a hydrolysis resistant polypeptide that marries the potential for expansive modification with synthetic control. This polymer, poly(γ-propargyl-L-glutamine) may be prepared from commercially available or previously synthesized poly(L-glutamate) by routine amide bond coupling reactions on a multi gram scale. Afterwards, the polymer may be altered to suit many applications through modification of the side chains or end group by orthogonal and quantitative reactions. The ease of synthesis and versatile nature of poly(γ-propargyl-L-glutamine) makes it a unique and ideal scaffold for biomaterial applications.

中文翻译：

用于生物材料的抗水解功能多肽支架†

对于生物材料而言，丰富的功能通常要以对结构的精确控制为代价。在本文中，我们开发了一种抗水解多肽，该多肽具有通过合成控制进行广泛修饰的潜力。该聚合物聚（γ-炔丙基-L-谷氨酰胺）可以通过市售的或先前合成的聚（L-谷氨酸盐）通过常规的酰胺键偶联反应以多克规模制备。然后，可以通过正交和定量反应对侧链或端基进行改性，从而改变聚合物以适应多种应用。聚（γ-炔丙基-L-谷氨酰胺）易于合成且用途广泛，使其成为生物材料应用的独特且理想的支架。

更新日期：2017-12-21

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