Towards optimisation of surface enhanced photodynamic therapy of breast cancer cells using gold nanoparticle–photosensitiser conjugates†,Photochemical & Photobiological Sciences

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Towards optimisation of surface enhanced photodynamic therapy of breast cancer cells using gold nanoparticle–photosensitiser conjugates†
Photochemical & Photobiological Sciences ( IF 2.7 ) Pub Date : 2017-12-21 00:00:00 , DOI: 10.1039/c7pp00225d
Paula García Calavia _{1,

2,

3,

4,

5} , María J. Marín _{1,

2,

3,

4,

5} , Isabelle Chambrier _{1,

2,

3,

4,

5} , Michael J. Cook _{1,

2,

3,

4,

5} , David A. Russell _{1,

2,

3,

4,

5}

Affiliation

Gold nanoparticles (AuNPs; ca. 4 nm) were synthesised and functionalised with a mixed monolayer of polyethylene glycol (PEG) and one of two zinc phthalocyanines (ZnPcs), the difference between the two molecules was the length of the carbon chain that connects the Pc to the gold core. The chain was composed of either three (C3Pc) or eleven (C11Pc) carbon atoms. The C11Pc photosensitiser displayed higher fluorescence emission intensity than the C3Pc in solution. By contrast, the C3Pc photosensitiser exhibited higher fluorescence when bound to the surface of the AuNPs than the C11Pc, despite the shorter carbon chain which was expected to quench the fluorescence. In addition, the C3Pc nanoparticle conjugates exhibited an enhancement in the production of singlet oxygen (¹O₂). The metal-enhanced ¹O₂ production led to a remarkable photodynamic efficacy for the treatment of human breast cancer cells.

中文翻译：

使用金纳米粒子-光敏剂结合物优化乳腺癌细胞的表面增强光动力疗法†

合成金纳米颗粒（AuNPs;约4 nm），并用聚乙二醇（PEG）和两个锌酞菁（ZnPcs）之一的混合单层功能化，这两个分子之间的差异是连接碳纳米管的碳链的长度PC到金芯。该链由三个（C3Pc）或十一个（C11Pc）碳原子组成。与溶液中的C3Pc相比，C11Pc光敏剂显示出更高的荧光发射强度。相比之下，尽管C3Pc光敏剂结合到AuNPs的表面上比C11Pc表现出更高的荧光，尽管碳链较短，这有望使荧光淬灭。此外，C3Pc纳米颗粒共轭物在单线态氧（¹ O ₂）。金属增强的¹ O _2的产生导致用于治疗人类乳腺癌细胞的显着光动力功效。

更新日期：2017-12-21

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