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The failure of rodent carcinogenesis as a model for Man
Toxicology Research ( IF 2.2 ) Pub Date : 2017-12-20 00:00:00 , DOI: 10.1039/c7tx00283a Colin Berry 1
Toxicology Research ( IF 2.2 ) Pub Date : 2017-12-20 00:00:00 , DOI: 10.1039/c7tx00283a Colin Berry 1
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Recent advances in our understanding of the process of carcinogenesis in Man have required revision of our thinking about the classical initiation/promotion sequence; understanding must now encompass the roles of both genetic and epigenetic change, realisation of the importance of the variable genetic backgrounds of the tumour bearers in any group and an understanding of the importance of random genetic events over time. The behavior of tumours, once established, is more complex than has been thought. Current views of the processes involved are not modelled in toxicity testing programmes.
中文翻译：
啮齿动物致癌作为人类模型的失败
我们对人类致癌过程理解的最新进展要求我们修正对经典起始/促进序列的看法。现在的理解必须涵盖遗传和表观遗传变化的作用，认识到任何群体中肿瘤携带者的可变遗传背景的重要性，并理解随着时间的推移随机遗传事件的重要性。肿瘤一旦形成，其行为就比想象的要复杂。当前对所涉及过程的看法并未在毒性测试计划中建模。
更新日期：2017-12-20
中文翻译：
啮齿动物致癌作为人类模型的失败
我们对人类致癌过程理解的最新进展要求我们修正对经典起始/促进序列的看法。现在的理解必须涵盖遗传和表观遗传变化的作用，认识到任何群体中肿瘤携带者的可变遗传背景的重要性，并理解随着时间的推移随机遗传事件的重要性。肿瘤一旦形成，其行为就比想象的要复杂。当前对所涉及过程的看法并未在毒性测试计划中建模。
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