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Isolation, Structural Elucidation, and Liquid Chromatography–Mass Spectrometry Analysis of Steroidal Glycosides from Polygonatum odoratum
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2018-01-04 00:00:00 , DOI: 10.1021/acs.jafc.7b04488 Qingbo Liu 1 , Wei Li 1 , Kazuya Nagata 1 , Hongwei Fu 2 , Shunpei Okada 1 , Ikumi Tanabe 1 , Yumi Kobori 1 , Koji Higai 1 , Wada Norie 1 , Tatsunori Sasaki 1 , Yoshihisa Asada 1 , Huanxin Zhao 3 , Hong Bai 4 , Kazuo Koike 1
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2018-01-04 00:00:00 , DOI: 10.1021/acs.jafc.7b04488 Qingbo Liu 1 , Wei Li 1 , Kazuya Nagata 1 , Hongwei Fu 2 , Shunpei Okada 1 , Ikumi Tanabe 1 , Yumi Kobori 1 , Koji Higai 1 , Wada Norie 1 , Tatsunori Sasaki 1 , Yoshihisa Asada 1 , Huanxin Zhao 3 , Hong Bai 4 , Kazuo Koike 1
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The rhizomes of Polygonatum odoratum represent a traditional Chinese medicine and functional food. A phytochemical investigation resulted in the isolation of eight steroidal glycosides (1–8), including two new compounds, polygonatumosides F (1) and G (2). The structures were elucidated by spectroscopic data and chemical reactions. Compound 7 showed antiproliferation activity against human hepatocellular carcinoma cell line HepG2 (IC50 of 3.2 μM). The chemical profile and contents of steroidal glycosides of P. odoratum rhizomes collected at different dates and geographical locations were also investigated, indicating that the rational harvest of P. odoratum in spring and autumn is preferable to obtain higher levels of steroidal glycosides. Compounds 1 and 7 showed the highest contents in all P. odoratum samples and have potential to serve as chemotaxonomic and chemical markers for quality control of this important plant material. 14-Hydroxylation may be a key step for the biosynthesis of compounds 1–7.
中文翻译：
玉竹中甾体糖苷的分离，结构鉴定和液相色谱-质谱联用
玉竹的根茎代表传统中药和功能性食品。的植物化学研究导致了八个甾体糖苷（隔离1 - 8），包括两个新的化合物，polygonatumosides F（1）和G（2）。通过光谱数据和化学反应阐明了结构。化合物7对人肝癌细胞系HepG2表现出抗增殖活性（IC 50为3.2μM）。香假单胞菌甾体苷的化学成分和含量还对在不同日期和地理位置收集的根茎进行了调查，表明在春季和秋季合理收获香竹有助于获得更高水平的甾体糖苷。化合物1和7在所有香竹样品中均显示最高含量，并有可能用作化学分类和化学标记，以控制这种重要植物材料的质量。14羟基化可以是对化合物的生物合成中的关键步骤1 - 7。
更新日期：2018-01-04
中文翻译：
玉竹中甾体糖苷的分离，结构鉴定和液相色谱-质谱联用
玉竹的根茎代表传统中药和功能性食品。的植物化学研究导致了八个甾体糖苷（隔离1 - 8），包括两个新的化合物，polygonatumosides F（1）和G（2）。通过光谱数据和化学反应阐明了结构。化合物7对人肝癌细胞系HepG2表现出抗增殖活性（IC 50为3.2μM）。香假单胞菌甾体苷的化学成分和含量还对在不同日期和地理位置收集的根茎进行了调查，表明在春季和秋季合理收获香竹有助于获得更高水平的甾体糖苷。化合物1和7在所有香竹样品中均显示最高含量，并有可能用作化学分类和化学标记，以控制这种重要植物材料的质量。14羟基化可以是对化合物的生物合成中的关键步骤1 - 7。
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