The presence of diabetes increases the risk of an amputation of a leg, foot, or toe by approximately 23 times that of a person without diabetes. Most amputations in people with diabetes are preceded by ulceration of the foot, and it is estimated that around 7000 people with diabetes are affected by ulceration of the foot at any one time in England. Caring for people with ulcers and trying to improve healing to avoid amputations is hugely expensive to the UK National Health Service, with costs estimated to be approximately £1 billion per year.

中文翻译：

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神经缺血性糖尿病足溃疡的治疗策略

糖尿病的存在会使腿，脚或脚趾被截肢的风险增加，而没有糖尿病的人则被截肢的风险大约是其23倍。糖尿病人的大多数截肢手术都是在脚溃疡之前进行的，据估计在英格兰，大约有7000人在任何时候都受到脚溃疡的影响。照料患有溃疡的人并试图改善愈合状况以免截肢对英国国家卫生局来说是非常昂贵的，估计每年的费用约为10亿英镑。