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Dietary cumulative acute risk assessment of organophosphorus, carbamates and pyrethroids insecticides for the Brazilian population
Food and Chemical Toxicology ( IF 3.9 ) Pub Date : 2017-12-20 , DOI: 10.1016/j.fct.2017.12.010
Andreia Nunes Oliveira Jardim , Alessandra Page Brito , Gerda van Donkersgoed , Polly E. Boon , Eloisa Dutra Caldas

Cumulative acute dietary risk assessments of organophosphorus (OPs), carbamates (CBs) and pyrethroids (PYs) were conducted for the Brazilian population. Residue data for 30786 samples of 30 foods were obtained from two national monitoring programs and one University laboratory, and consumption data from a national survey conducted among persons 10 years or older. Acephate and methamidophos were used as index compounds (IC) for OPs, oxamyl for CBs and deltamethrin for PYs. Exposures were estimated using the Monte Carlo Risk Assessment (MCRA 8.2) software. Orange and orange juice (mainly containing methidathion), pasta and salted bread (mainly pirimiphos-methyl) contributed most to the OPs intake. Rice accounted for 80% of the CBs intake (teenagers), mainly due to aldicarb. Pasta, salted bread and beans contributed most to the PYs intake (9–14%), mainly due to bifenthrin. The intake did not exceed the ARfD at the 99.9th percentile for OPs, CBs and PYs, and the risks from the exposure were not considered of health concern. When food consumption data become available for children under age 10, studies in the cumulative exposure should be conducted, as this age group is the most critical among the population, mainly due to their higher food consumption per kg body weight.



中文翻译:

巴西人群中有机磷,氨基甲酸酯和拟除虫菊酯类农药的膳食累积急性风险评估

对巴西人口进行了有机磷(OPs),氨基甲酸酯(CBs)和拟除虫菊酯(PYs)的累积急性饮食风险评估。从两个国家监测计划和一个大学实验室获得了30786种食物的30786个样品的残留数据,而消费数据则来自对10岁以上人群进行的国家调查。乙炔和甲胺磷用作OP的指标化合物(IC),乙酰胺用作CB的指标化合物,溴氰菊酯用于PY的指标化合物(IC)。使用蒙特卡洛风险评估(MCRA 8.2)软件估算暴露量。橙汁和橙汁(主要含有甲硫磷),面食和盐制面包(主要为甲基嘧啶磷)是OPs摄入量最大的原因。大米占CBs摄入量(青少年)的80%,主要归因于涕灭威。面食,咸面包和豆类是PY摄入量的主要来源(9–14%),主要是由于联苯菊酯。OPs,CBs和PYs的摄入量不超过ARfD的99.9个百分点,并且不考虑健康带来的风险。当获得10岁以下儿童的食物消费数据时,应进行累积暴露量研究,因为该年龄组是人口中最关键的人群,这主要是由于他们每公斤体重的食物消费量较高。

更新日期:2017-12-20
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