Tumor microenvironment with hypoxia and excess hydrogen peroxide (H₂O₂) tremendously limits the effect of chemoradiation therapy of colorectal cancer. For the first time, we developed a facile method to deposit manganese dioxide (MnO₂) on the surface of albumin bound paclitaxel nanoparticles (ANPs-PTX) to obtain MnO₂-functioned ANPs-PTX (MANPs-PTX). In the tumor microenvironment, MANPs-PTX could consume excess hydrogen peroxide (H₂O₂) to produce abundant oxygen for tumor oxygenation and improve chemoradiation therapy. Meanwhile, the released Mn²⁺ from MANPs-PTX had excellent T₁ magnetic resonance imaging (MRI) performances for tumor detection. Notably, the obtained MANPs-PTX would be a promising theranostic agent and have potential clinical application prospects.

中文翻译：

---

轻松沉积到白蛋白结合的紫杉醇纳米粒子上的二氧化锰，用于调节缺氧肿瘤微环境以改善化学放射治疗

具有低氧和过量过氧化氢（H ₂ O ₂）的肿瘤微环境极大地限制了结直肠癌化学放疗的效果。首次，我们开发了一种简便的方法来在白蛋白结合的紫杉醇纳米颗粒（ANPs-PTX）的表面上沉积二氧化锰（MnO ₂），以获得具有MnO ₂功能的ANPs-PTX（MANPs-PTX）。在肿瘤微环境中，MANPs-PTX可以消耗过量的过氧化氢（H ₂ O ₂）产生大量的氧用于肿瘤氧合，并改善化学放射疗法。同时，从MANPs-PTX释放的Mn ²⁺具有优异的T _1。磁共振成像（MRI）用于肿瘤检测的性能。值得注意的是，所获得的MANPs-PTX将是有前途的治疗剂，并具有潜在的临床应用前景。