A Combined Tamaru Allylation/Olefin Cross-Metathesis Approach for the Total Syntheses of (±)-Paniculidine B, (±)-Paniculidine C, and 2-Methylcarbazole,Synlett

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A Combined Tamaru Allylation/Olefin Cross-Metathesis Approach for the Total Syntheses of (±)-Paniculidine B, (±)-Paniculidine C, and 2-Methylcarbazole
Synlett ( IF 1.7 ) Pub Date : 2017-12-20 , DOI: 10.1055/s-0036-1591739
Yen-Ku Wu ₁ , Yi-Lun Tseng ₁ , Min-Chieh Liang ₁ , I-Chia Chen ₂

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A concise approach to the total syntheses of racemic paniculidines B and C is described. The route features a combined Tamaru allylation/olefin cross-metathesis sequence for the regiocontrolled synthesis of prenylindole intermediates. In addition, we report a transformation of the prenylated indole into 2-methylcarbazole catalyzed by sulfonic acid-functionalized silica gel.

中文翻译：

用于 (±)-Paniculidine B、(±)-Paniculidine C 和 2-甲基咔唑全合成的 Tamaru 烯丙基化/烯烃交叉复分解方法

描述了外消旋paniculidines B 和C 全合成的简明方法。该路线的特点是结合了 Tamaru 烯丙基化/烯烃交叉复分解序列，用于异戊二烯中间体的区域控制合成。此外，我们报告了在磺酸官能化硅胶的催化下异戊二烯化吲哚转化为 2-甲基咔唑的过程。

更新日期：2017-12-20

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