Currently, noninvasive glucose monitoring is not widely appreciated because of its uncertain measurement accuracy, weak blood glucose correlation, and inability to detect hyperglycemia/hypoglycemia during sleep. We present a strategy to design and fabricate a skin-like biosensor system for noninvasive, in situ, and highly accurate intravascular blood glucose monitoring. The system integrates an ultrathin skin-like biosensor with paper battery-powered electrochemical twin channels (ETCs). The designed subcutaneous ETCs drive intravascular blood glucose out of the vessel and transport it to the skin surface. The ultrathin (~3 μm) nanostructured biosensor, with high sensitivity (130.4 μA/mM), fully absorbs and measures the glucose, owing to its extreme conformability. We conducted in vivo human clinical trials. The noninvasive measurement results for intravascular blood glucose showed a high correlation (>0.9) with clinically measured blood glucose levels. The system opens up new prospects for clinical-grade noninvasive continuous glucose monitoring.

中文翻译：

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皮肤样生物传感器系统通过电化学通道进行无创血糖监测。

当前，无创血糖监测由于其不确定的测量准确性，弱的血糖相关性以及无法在睡眠期间检测到高血糖/低血糖而未被广泛认可。我们提出了一种策略，用于设计和制造用于无创，原位和高精度血管内血糖监测的类似皮肤的生物传感器系统。该系统将超薄的类似于皮肤的生物传感器与纸电池供电的电化学双通道（ETC）集成在一起。设计的皮下ETC将血管内血糖驱出血管，并将其运输到皮肤表面。具有超高灵敏度（130.4μA/ mM）的超薄（〜3μm）纳米结构生物传感器，由于其极好的适应性，可以完全吸收和测量葡萄糖。我们进行了体内人类临床试验。血管内血糖的非侵入性测量结果显示与临床测量的血糖水平高度相关（> 0.9）。该系统为临床级无创连续血糖监测开辟了新的前景。