Contribution of Maternal Antiretroviral Therapy and Breastfeeding to 24-Month Survival in Human Immunodeficiency Virus-Exposed Uninfected Children: An Individual Pooled Analysis of African and Asian Studies,Clinical Infectious Diseases

当前位置： X-MOL 学术 › Clin. Infect. Dis. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Contribution of Maternal Antiretroviral Therapy and Breastfeeding to 24-Month Survival in Human Immunodeficiency Virus-Exposed Uninfected Children: An Individual Pooled Analysis of African and Asian Studies
Clinical Infectious Diseases ( IF 8.2 ) Pub Date : 2017-12-21 , DOI: 10.1093/cid/cix1102
Shino Arikawa ₁ , Nigel Rollins ₂ , Gonzague Jourdain _{3,

4,

5} , Jean Humphrey ₆ , Athena P Kourtis _{7,

8} , Irving Hoffman ₉ , Max Essex ₅ , Tim Farley ₁₀ , Hoosen M Coovadia ₁₁ , Glenda Gray _{12,

13} , Louise Kuhn ₁₄ , Roger Shapiro ₅ , Valériane Leroy ₁₅ , Robert C Bollinger ₁₆ , Carolyne Onyango-Makumbi ₁₇ , Shahin Lockman ₅ , Carina Marquez ₁₈ , Tanya Doherty ₁₂ , François Dabis ₁ , Laurent Mandelbrot ₁₉ , Sophie Le Coeur _{3,

4,

5,

20} , Matthieu Rolland ₁ , Pierre Joly ₂₁ , Marie-Louise Newell ₂₂ , Renaud Becquet ₁

Affiliation

University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Team IDLIC, France.
Department of Maternal, Newborn, Child and Adolescent Health, World Health Organization, Geneva, Switzerland.
Institut de recherche pour le développement UMI 174-PHPT, Marseille, France.
Faculty of Associated Medical Sciences, Chiang Mai University, Thailand.
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Department of International Health, Center for Global Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Women's Health and Fertility Branch, Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention.
Emory University School of Medicine and Eastern Virginia Medical School, Atlanta, Georgia.
Division of Infectious Diseases, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill.
Sigma3 Services SÀRL, Nyon, Switzerland.
Maternal Adolescent and Child Health, University of the Witwatersrand, Johannesburg.
South African Medical Research Council, Cape Town.
Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
Gertrude H. Sergievsky Center, College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.
Inserm, Centre de recherche Inserm U1027, Université Paul Sabatier Toulouse 3, France.
Center for Clinical Global Health Education, Johns Hopkins University, Baltimore, Maryland.
Makerere University-Johns Hopkins University Research Collaboration/MU-JHU CARE LTD, Kampala, Uganda.
Division of HIV, Infectious Diseases and Global Medicine, University of California San Francisco, and Zuckerberg San Francisco General Hospital.
University Paris-Diderot, Assitance Publique Hôpitaux de Paris.
Institut National d'Etudes Démographiques (Ined), Paris.
University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Team Biostatistics, France.
Institute for Developmental Science and Global Health Research Institute, Faculty of Medicine, University of Southampton, United Kingdom.

Human immunodeficiency virus (HIV)–infected pregnant women increasingly receive antiretroviral therapy (ART) to prevent mother-to-child transmission (PMTCT). Studies suggest HIV-exposed uninfected (HEU) children face higher mortality than HIV-unexposed children, but most evidence relates to the pre-ART era, breastfeeding of limited duration, and considerable maternal mortality. Maternal ART and prolonged breastfeeding while on ART may improve survival, although this has not been reliably quantified.

中文翻译：

母亲抗逆转录病毒治疗和母乳喂养对暴露于人类免疫缺陷病毒的未感染儿童 24 个月生存的贡献：非洲和亚洲研究的个体汇总分析

感染人类免疫缺陷病毒 (HIV) 的孕妇越来越多地接受抗逆转录病毒治疗 (ART)，以预防母婴传播 (PMTCT)。研究表明，接触艾滋病毒的未感染儿童 (HEU) 比未接触艾滋病毒的儿童面临更高的死亡率，但大多数证据与 ART 之前的时代、母乳喂养时间有限以及相当大的孕产妇死亡率有关。母亲抗逆转录病毒治疗和接受抗逆转录病毒治疗期间延长母乳喂养可能会提高生存率，尽管这一点尚未得到可靠的量化。

更新日期：2017-12-21

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11