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Oral contraceptive use as a determinant of plasma concentrations of perfluoroalkyl substances among women in the Norwegian Mother and Child Cohort (MoBa) study
Environment International ( IF 10.3 ) Pub Date : 2017-12-20 , DOI: 10.1016/j.envint.2017.12.015
Elise L. Rush , Alison B. Singer , Matthew P. Longnecker , Line S. Haug , Azemira Sabaredzovic , Elaine Symanski , Kristina W. Whitworth

Objective

Because oral contraceptives (OC) tends to lessen menstrual fluid loss – a route of excretion for perfluoroalkyl substances (PFASs) – we hypothesized that such use would be positively associated with PFAS concentrations.

Methods

This analysis was based on the Norwegian Mother and Child Cohort (MoBa) study. We included 1090 women from two previous substudies of women enrolled from 2003 to 2007. Characteristics of OC use were obtained at baseline: use in the past 12 months, duration and recency of use, age at first use. We examined log-transformed plasma concentrations of seven PFASs (perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnDA), perfluorohexane sulfonate (PFHxS), perfluoroheptane sulfonate (PFHpS), and perfluorooctane sulfonate (PFOS)). Linear regression analyses, adjusted for maternal age, menstrual cycle length, parity, and education, were used to examine whether OC use characteristics were determinants of PFAS concentrations.

Results

Except for PFDA and PFUnDA, women who used OCs in the 12 months preceding the baseline interview had 12.9–35.7% higher PFAS concentrations than never OC users. To a lesser extent, past OC use was positively associated with PFASs (estimates ranged from 7.2–32.1%). Compared with never users, using OCs for 10 or more years was associated with increased PFAS concentrations, except for PFDA and PFUnDA (estimates for other PFASs ranged from 18.9–46.2%). We observed little effect of age at first OC use.

Conclusions

This analysis shows that characteristics of OC use, and duration of use in particular, may be important considerations when investigating relationships between women's reproductive outcomes and PFASs.



中文翻译:

挪威母亲和儿童队列(MoBa)研究中口服避孕药可确定妇女血浆中全氟烷基物质的浓度

客观的

因为口服避孕药(OC)倾向于减少月经量减少(一种全氟烷基物质(PFASs)的排泄途径),所以我们假设这种用法与PFAS浓度呈正相关。

方法

该分析基于挪威母婴队列(MoBa)研究。我们纳入了2003年至2007年的前两个子研究中的1090名妇女。OC的使用特征是在基线获得的:过去12个月的使用,使用的持续时间和新近度,首次使用的年龄。我们检查了七个PFAS(全氟辛酸(PFOA),全氟壬酸(PFNA),全氟癸酸(PFDA),全氟十一酸(PFUnDA),全氟己烷磺酸盐(PFHxS),全氟庚烷磺酸盐(PFHpS)和对氟辛烷磺酸(PFHpS)的对数转换后血浆浓度(PFOS))。根据产妇年龄,月经周期长度,胎次和受教育程度进行调整的线性回归分析用于检查OC的使用特征是否是PFAS浓度的决定因素。

结果

除了PFDA和PFUnDA之外,在基线访谈之前的12个月内使用过OC的女性比从未使用过OC的女性高出12.9–35.7%。在较小程度上,过去的OC使用与PFAS正相关(估计范围为7.2–32.1%)。与从未使用过的用户相比,使用10年或10年以上的OC会增加PFAS的浓度,但PFDA和PFUnDA除外(其他PFAS的估计范围为18.9–46.2%)。我们观察到初次使用OC对年龄的影响很小。

结论

该分析表明,在调查妇女的生殖结局与PFAS之间的关系时,OC的使用特征(尤其是使用时间)可能是重要的考虑因素。

更新日期:2017-12-21
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