Synthesis and Structure–Activity Relationship Study of Biliatresone, a Plant Isoflavonoid That Causes Biliary Atresia,ACS Medicinal Chemistry Letters

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Synthesis and Structure–Activity Relationship Study of Biliatresone, a Plant Isoflavonoid That Causes Biliary Atresia
ACS Medicinal Chemistry Letters ( IF 3.5 ) Pub Date : 2017-12-20 00:00:00 , DOI: 10.1021/acsmedchemlett.7b00479
Michelle A. Estrada ₁ , Xiao Zhao ₂ , Kristin Lorent ₂ , Alyssa Kriegermeier ₃ , Seika A. Nagao ₁ , Simon Berritt ₁ , Rebecca G. Wells _{2,

4,

5} , Michael Pack _{2,

6} , Jeffrey D. Winkler ₁

Affiliation

We report the first synthesis of the plant isoflavonoid biliatresone. The convergent synthesis has been applied to the synthesis of several analogs, which have facilitated the first structure–activity relationship study for this environmental toxin that, on ingestion, recapitulates the phenotype of biliary atresia.

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