Impacts of broth chemistry on silver ion release, surface chemistry composition, and bacterial cytotoxicity of silver nanoparticles†,Environmental Science: Nano

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Impacts of broth chemistry on silver ion release, surface chemistry composition, and bacterial cytotoxicity of silver nanoparticles†
Environmental Science: Nano ( IF 5.8 ) Pub Date : 2017-12-20 00:00:00 , DOI: 10.1039/c7en00974g
Kathryn A. Johnston _{1,

2,

3,

4} , Lisa M. Stabryla _{2,

3,

4,

5} , Ashley M. Smith _{1,

2,

3,

4} , Xing Yee Gan _{1,

2,

3,

4} , Leanne M. Gilbertson _{2,

3,

4,

5} , Jill E. Millstone _{1,

2,

3,

4,

6}

Affiliation

Here, we determine the impact of bacterial growth media on silver nanoparticle (diameter = 24.0 ± 3.2 nm) surface chemistry, the relationship of this surface chemistry to silver ion release from these nanoparticles, and ultimately the antimicrobial implications of those parameters. Importantly, we investigate the effects of multiple broths, as well as the isolated influence of individual broth components and their bicombinations. Our findings indicate that, in combination, broth components may exhibit additive, synergistic, and/or antagonistic effects on silver ion release. In addition, we find that the silver ion release does not always inversely correlate with ligand density, and interestingly, that the type of correlation (negative or positive) is dependent on the broth media. Finally, the impact of these media-dependent silver ion release profiles on bacterial cytotoxicity is studied using the model organism Escherichia coli. Overall, we establish the specific impacts of silver nanoparticle environment on silver nanoparticle surface chemistry, as well as the influence of those outcomes on bacteria growth in the presence of silver nanoparticles.

中文翻译：

肉汤化学对银纳米颗粒释放银离子，表面化学组成和细菌细胞毒性的影响†

在这里，我们确定细菌生长培养基对银纳米颗粒（直径= 24.0±3.2 nm）表面化学的影响，该表面化学与这些纳米颗粒释放的银离子的关系，以及最终这些参数的抗菌影响。重要的是，我们研究了多种肉汤的效果，以及各个肉汤成分及其双组合的孤立影响。我们的发现表明，结合起来，肉汤成分可能对银离子的释放表现出累加，协同和/或拮抗作用。此外，我们发现银离子的释放并不总是与配体密度成反比，有趣的是，相关的类型（负或正）取决于肉汤培养基。最后，大肠杆菌。总体而言，我们确定了银纳米颗粒环境对银纳米颗粒表面化学的特定影响，以及这些结果对存在银纳米颗粒时细菌生长的影响。

更新日期：2017-12-20

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