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Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2017-12-20 , DOI: 10.1021/acs.jnatprod.7b00732 Santana A L Thomas , Jacqueline L von Salm , Shane Clark , Steve Ferlita , Prasanth Nemani , Ala Azhari , Christopher A Rice , Nerida G Wilson 1 , Dennis E Kyle , Bill J Baker
Journal of Natural Products ( IF 3.3 ) Pub Date : 2017-12-20 , DOI: 10.1021/acs.jnatprod.7b00732 Santana A L Thomas , Jacqueline L von Salm , Shane Clark , Steve Ferlita , Prasanth Nemani , Ala Azhari , Christopher A Rice , Nerida G Wilson 1 , Dennis E Kyle , Bill J Baker
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During a 2013 cruise in the Southern Ocean we collected specimens of the octocoral Plumarella delicatissima between 800 and 950 m depth. Five new furanocembranoid diterpenes, keikipukalides A-E (1-5), the known diterpene pukalide aldehyde (6), and the known norditerpenoid ineleganolide (7) were isolated from the coral. These Plumarella terpenes lack mammalian cytotoxicity, while 2-7 display activity against Leishmania donovani between 1.9 and 12 μM. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy and mass spectrometry, and keikipukalides A and E were confirmed by X-ray crystallography.
中文翻译：
Keikipukalides，来自南极深海 Octocoral Plumarella delicatissima 的呋喃西松二萜。
2013 年在南大洋航行期间，我们在 800 至 950 米深度之间采集了 Plumarella delicatissima 八珊瑚的标本。从珊瑚中分离出五种新的呋喃西松二萜类化合物：keikipukalides AE (1-5)、已知的二萜 pukalide 醛 (6) 和已知的降二萜 ineleganolide (7)。这些 Plumarella 萜烯缺乏哺乳动物细胞毒性，而 2-7 在 1.9 至 12 μM 之间显示出抗杜氏利什曼原虫的活性。一维和二维核磁共振波谱和质谱有助于结构阐明，并且 keikipukalides A 和 E 通过 X 射线晶体学得到证实。
更新日期：2017-12-20
中文翻译：
Keikipukalides，来自南极深海 Octocoral Plumarella delicatissima 的呋喃西松二萜。
2013 年在南大洋航行期间，我们在 800 至 950 米深度之间采集了 Plumarella delicatissima 八珊瑚的标本。从珊瑚中分离出五种新的呋喃西松二萜类化合物：keikipukalides AE (1-5)、已知的二萜 pukalide 醛 (6) 和已知的降二萜 ineleganolide (7)。这些 Plumarella 萜烯缺乏哺乳动物细胞毒性，而 2-7 在 1.9 至 12 μM 之间显示出抗杜氏利什曼原虫的活性。一维和二维核磁共振波谱和质谱有助于结构阐明，并且 keikipukalides A 和 E 通过 X 射线晶体学得到证实。
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