Multiple stimuli-responsive selenium-functionalized biodegradable starch-based hydrogels†,Soft Matter

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Multiple stimuli-responsive selenium-functionalized biodegradable starch-based hydrogels†
Soft Matter ( IF 2.9 ) Pub Date : 2017-12-20 00:00:00 , DOI: 10.1039/c7sm02137b
Tongbing Sun _{1,

2,

3,

4,

5} , Caizhen Zhu _{1,

2,

3,

4} , Jian Xu _{4,

5,

6,

7,

8}

Affiliation

Novel biodegradable diselenide cross-linked starch-based hydrogels were synthesized via free radical copolymerization, which serve as stimuli-responsive drug release materials composed of starch chain backbones with an enzyme hydrolysis property and selenium-containing cross-linkers with a redox responsive cleavage property. Rhodamine B (RB) loaded starch-based hydrogels were prepared in order to investigate their stimuli-responsive release behaviours. In the presence of external redox agents, the enzyme stimuli as well as the mixture of the above stimuli, the prepared starch-based hydrogels exhibit controlled multi-responsive release behavior of RB. Overall, the merits of good biodegradation and multi-stimuli responsiveness make these kinds of starch-based hydrogels promising biomedical candidates for the realization of controlled drug delivery.

中文翻译：

多种刺激响应性硒官能化的可生物降解淀粉基水凝胶†

新型可生物降解的二硒化物交联淀粉基水凝胶是通过自由基共聚，它是由具有酶水解特性的淀粉链主链和具有氧化还原响应性裂解特性的含硒交联剂组成的刺激响应药物释放材料。制备了罗丹明B（RB）的淀粉基水凝胶，以研究其刺激应答性释放行为。在外部氧化还原剂，酶刺激物以及上述刺激物的混合物的存在下，制备的淀粉基水凝胶表现出受控的RB多反应释放行为。总体而言，良好的生物降解和多重刺激响应能力的优点使这类基于淀粉的水凝胶有望成为实现药物控释的生物医学候选者。

更新日期：2017-12-20

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