Calcium-based biomaterials for diagnosis, treatment, and theranostics,Chemical Society Reviews

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Calcium-based biomaterials for diagnosis, treatment, and theranostics
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2017-12-20 00:00:00 , DOI: 10.1039/c6cs00746e
Chao Qi _{1,

2,

3,

4,

5} , Jing Lin _{1,

2,

3,

4,

5} , Lian-Hua Fu _{1,

2,

3,

4,

5} , Peng Huang _{1,

2,

3,

4,

5}

Affiliation

Calcium-based (CaXs) biomaterials including calcium phosphates, calcium carbonates, calcium silicate and calcium fluoride have been widely utilized in the biomedical field owing to their excellent biocompatibility and biodegradability. In recent years, CaXs biomaterials have been strategically integrated with imaging contrast agents and therapeutic agents for various molecular imaging modalities including fluorescence imaging, magnetic resonance imaging, ultrasound imaging or multimodal imaging, as well as for various therapeutic approaches including chemotherapy, gene therapy, hyperthermia therapy, photodynamic therapy, radiation therapy, or combination therapy, even imaging-guided therapy. Compared with other inorganic biomaterials such as silica-, carbon-, and gold-based biomaterials, CaXs biomaterials can dissolve into nontoxic ions and participate in the normal metabolism of organisms. Thus, they offer safer clinical solutions for disease theranostics. This review focuses on the state-of-the-art progress in CaXs biomaterials, which covers from their categories, characteristics and preparation methods to their bioapplications including diagnosis, treatment, and theranostics. Moreover, the current trends and key problems as well as the future prospects and challenges of CaXs biomaterials are also discussed at the end.

中文翻译：

用于诊断，治疗和治疗诊断的钙基生物材料

包括磷酸钙，碳酸钙，硅酸钙和氟化钙在内的钙基（CaXs）生物材料因其出色的生物相容性和生物降解性而被广泛应用于生物医学领域。近年来，CaXs生物材料已与成像造影剂和治疗剂进行了战略性集成，可用于各种分子成像方式，包括荧光成像，磁共振成像，超声成像或多峰成像，以及用于各种治疗方法，包括化学疗法，基因治疗，体温过高疗法，光动力疗法，放射疗法或联合疗法，甚至影像引导疗法。与其他无机生物材料（如二氧化硅，碳和金基生物材料）相比，CaXs生物材料可以溶解为无毒离子，并参与生物体的正常代谢。因此，它们为疾病治疗诊断学提供了更安全的临床解决方案。这篇综述着重于CaXs生物材料的最新进展，涵盖了从其类别，特征和制备方法到其生物应用（包括诊断，治疗和诊断学）的范围。此外，最后还讨论了CaXs生物材料的当前趋势和关键问题以及未来的前景和挑战。治疗和治疗学。此外，最后还讨论了CaXs生物材料的当前趋势和关键问题以及未来的前景和挑战。治疗和治疗学。此外，最后还讨论了CaXs生物材料的当前趋势和关键问题以及未来的前景和挑战。

更新日期：2017-12-20

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