The therapeutic effectiveness of a drug largely depends on its bioavailability, and thus ultimately on its aqueous solubility. Hydrotropes are compounds able to enhance the solubility of hydrophobic substances in aqueous media and therefore are extensively used in the formulation of drugs and personal care products. Recently, some ionic liquids were shown to display a strong ability to enhance the solubility of biomolecules through hydrotropy. In this work, the impact of the ionic liquid chemical structures and their concentration on the solubility of ibuprofen was evaluated and compared with the performance of conventional hydrotropes. The results obtained clearly evidence the exceptional capacity of ionic liquids to enhance the solubility of ibuprofen. [C₄C₁im][SCN] and [C₄C₁im][N(CN)₂] seem to be the most promising ionic liquids for ibuprofen solubilisation, where an increase in the solubility of 60- and 120-fold was observed with ionic liquid concentrations of circa 1 mol kg⁻¹, respectively. Dynamic light scattering and molecular dynamics simulations were used to investigate the mechanism of the IL-mediated drug solubility and the results obtained indicate that the structure of aqueous solutions of ionic liquids and the role it plays in the formation of ionic liquid-drug aggregates is the mechanism driving the hydrotropic dissolution.

中文翻译：

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使用离子液体作为阳离子水溶助长剂可增强布洛芬的溶解度†

药物的治疗效果在很大程度上取决于其生物利用度，并最终取决于其水溶性。水溶助长剂是能够增强疏水性物质在水性介质中的溶解度的化合物，因此广泛用于药物和个人护理产品的配制中。近来，一些离子液体显示出显示出通过水溶性增强生物分子的溶解性的强大能力。在这项工作中，评估了离子液体化学结构及其浓度对布洛芬溶解度的影响，并与常规水溶助长剂的性能进行了比较。获得的结果清楚地证明了离子液体增强布洛芬溶解性的非凡能力。[C ₄ C ₁ im] [SCN]和[C₄ C ₁ im] [N（CN） ₂ ]似乎是布洛芬增溶的最有希望的离子液体，其中离子液体浓度约为1 mol kg ^-1时，可观察到60倍和120倍的溶解度增加， 分别。动态光散射和分子动力学模拟用于研究IL介导的药物溶解度的机制，所得结果表明离子液体水溶液的结构及其在离子液体药物聚集体形成中的作用是推动水溶作用的机理。