We report a facile and large-scale synthesis of size-tunable and nontoxic mesoporous silica-coated Gd₂O₃:Eu³⁺ (Gd@mSi) core–shell nanostructures using a TPAOH assisted modified UHP technique. The role of TPAOH in controlling the particle size was evaluated. The potentiality of these Gd@mSi core–shell nanoparticles before and after folic acid conjugation was established by in vitro fluorescence microscopy of the U2OS cell lines for cancer imaging and therapy.

中文翻译：

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TPAOH辅助尺寸可调的Gd ₂ O ₃ @mSi核-壳纳米结构，用于多功能生物医学应用

我们报告了使用TPAOH辅助改性的UHP技术轻松，大规模合成尺寸可调且无毒的介孔二氧化硅涂层的Gd ₂ O ₃：Eu ³⁺（Gd @ mSi）核-壳纳米结构。评估了TPAOH在控制粒径方面的作用。在叶酸结合前后，这些Gd @ mSi核壳纳米粒子的潜力是通过U2OS细胞系的体外荧光显微术确定的，用于癌症成像和治疗。