Selectins are vascular adhesion molecules that mediate physiological responses such as inflammation, immunity and hemostasis. During cancer progression, selectins promote various steps enabling the interactions between tumor cells and the blood constituents, including platelets, endothelial cells and leukocytes. Selectins are carbohydrate-binding molecules that bind to sialylated, fucosylated glycan structures. The increased selectin ligand expression on tumor cells correlates with enhanced metastasis and poor prognosis for cancer patients. While, many studies focused on the role of selectin as a mediator of tumor cell adhesion and extravasation during metastasis, there is evidence for selectins to activate signaling cascade that regulates immune responses within a tumor microenvironment. L-Selectin binding induces activation of leukocytes, which can be further modulated by selectin-mediated interactions with platelets and endothelial cells. Selectin ligand on leukocytes, PSGL-1, triggers intracellular signaling in leukocytes that are induced through platelet’s P-selectin or endothelial E-selectin binding. In this review, I summarize the evidence for selectin-induced immune modulation in cancer progression that represents a possible target for controlling tumor immunity.

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癌症免疫中的选择素

选择素是介导炎症、免疫和止血等生理反应的血管粘附分子。在癌症进展过程中，选择素促进各种步骤，使肿瘤细胞与血液成分（包括血小板、内皮细胞和白细胞）之间发生相互作用。选择素是与唾液酸化、岩藻糖基化聚糖结构结合的碳水化合物结合分子。肿瘤细胞上增加的选择素配体表达与癌症患者的转移增强和预后不良相关。虽然许多研究集中在选择素作为肿瘤细胞在转移过程中粘附和外渗的介质的作用，但有证据表明选择素可以激活调节肿瘤微环境内免疫反应的信号级联。L-选择素结合诱导白细胞活化，这可以通过选择素介导的与血小板和内皮细胞的相互作用来进一步调节。白细胞上的选择素配体 PSGL-1 在白细胞中触发细胞内信号传导，该信号通过血小板的 P-选择素或内皮 E-选择素结合诱导。在这篇综述中，我总结了选择素诱导的免疫调节在癌症进展中的证据，这代表了控制肿瘤免疫的可能目标。