We thank George Henderson and colleagues for their interest in our analysis. We agree that non-dietary factors such as genetic polymorphisms¹ affect biomarker levels of the omega-6 polyunsaturated fatty acids (PUFAs) linoleic acid and arachidonic acid. However, increased dietary linoleic acid increases linoleic acid biomarker levels in trials,² providing clear evidence that biomarker levels reasonably reflect dietary intake. We agree that compared with linoleic acid, arachidonic acid metabolism has a more prominent function than direct dietary intake in the regulation of biomarker levels.

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亚油酸和糖尿病的预防-作者的回复

我们感谢George Henderson及其同事对我们的分析感兴趣。我们同意，非饮食因素（例如遗传多态性^1）会影响omega-6多不饱和脂肪酸（PUFA）亚油酸和花生四烯酸的生物标志物水平。但是，在试验中，饮食中亚油酸含量的增加会增加亚油酸生物标记物的水平，[ ^2]提供了明确的证据，表明生物标记物的水平合理地反映了饮食摄入量。我们同意，与亚油酸相比，花生四烯酸的代谢在调节生物标志物水平方面比直接饮食摄入具有更突出的功能。