A Novel 18F-Labeling Method for the Synthesis of [18F]-Piperidine-Containing Ligands as Potential PET Radiotracers for σ Receptors,Synlett

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A Novel 18F-Labeling Method for the Synthesis of [18F]-Piperidine-Containing Ligands as Potential PET Radiotracers for σ Receptors
Synlett ( IF 1.7 ) Pub Date : 2017-12-19 , DOI: 10.1055/s-0036-1591734
Zibo Li ₁ , Qiu Wang ₂ , Gerardo Ortiz ₂ , Kantapat Chansaenpak _{1,

3} , Mengzhe Wang ₁ , Xiaofen Ma _{1,

4} , Hui Wang ₁

Affiliation

We report a novel 18 F-labeling method for the preparation of 18 F-containing piperidine derivatives. This method is demonstrated on the design and synthesis of 18 F-labeled potential PET radiotracers of σ receptors for initial biological evaluations. 1 Introduction 2 Design and Synthesis of Novel [ 19 F]-3 and [ 19 F]-3′ 3 Radiosynthesis of Novel [ 18 F]-3 and [ 18 F]-3′ 4 In vivo Uptake and Pharmacokinetics of [ 18 F]-3 and [ 18 F]-3′ 5 Conclusion

中文翻译：

一种用于合成 [18F]-哌啶配体作为 σ 受体潜在 PET 放射性示踪剂的新型 18F 标记方法

我们报告了一种新的 18 F 标记方法，用于制备含 18 F 的哌啶衍生物。该方法在 18 F 标记的 σ 受体的潜在 PET 放射性示踪剂的设计和合成上得到证明，用于初始生物学评估。1 引言 2 新型[ 19 F]-3 和[ 19 F]-3' 3 新型[ 18 F]-3 和[ 18 F]-3' 4 的放射合成[ 18 F] 的体内吸收和药代动力学]-3 和 [ 18 F]-3' 5 结论

更新日期：2017-12-19

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