A convenient and facile method was developed for the synthesis of 1,2,3-trisubstituted indolines. Starting from indole derivatives and ketones/aldehydes, the corresponding indoline products could be obtained with high yield by the hexamethylphosphoramide (HMPA) catalyzed indole Friedel–Crafts reaction, reduction and direct reductive amination process.

中文翻译：

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HMPA 催化一锅多步加氢法合成 1,2,3-三取代二氢吲哚

开发了一种方便简便的方法来合成 1,2,3-三取代二氢吲哚。以吲哚衍生物和酮/醛为原料，通过六甲基磷酰胺（HMPA）催化的吲哚Friedel-Crafts反应、还原和直接还原胺化过程，可以高产率地获得相应的二氢吲哚产物。