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Catalytic synthesis of alkyl (S,S)-O-Lactyllactates: Efficiency in action
Catalysis Communications ( IF 3.7 ) Pub Date : 2017-12-19 , DOI: 10.1016/j.catcom.2017.12.009
Valeriy S. Cherepakhin , Kirill V. Zaitsev

A new catalytic method for the synthesis of alkyl (S,S)-O-lactyllactates, HOCH(Me)C(O)OCH(Me)CO2R, 110 (R = Me, Et, n-Pr, i-Pr, n-Bu, i-Bu, i-Am, allyl, Cy, 3-HOC6H4CH2) was developed. Aluminum chloride catalyzes the reaction between l-lactide and a range of aliphatic alcohols under mild conditions. Corresponding alkyl lactyllactates may be isolated in high yields after distillation, what allows to perform separation from traces of corresponding lactates. It was established that AlCl3 reacts with alcohols with concomitant production of HCl and Al alkoxide complexes (like 11), which are both catalytically competent species for the alcoholysis of lactide.



中文翻译:

烷基(SS)-O-乳酸酯的催化合成:作用效率

一种新的催化方法,用于合成烷基(SS-O-乳酸酯,HOCH(Me)C(O)OCH(Me)CO 2 R,110(R = Me,Et,n -Pr,i -Pr,n- Bu,i- Bu,i- Am,烯丙基,Cy,3-HOC 6 H 4 CH 2)被开发。氯化铝催化的反应-丙交酯和各种脂肪醇在温和的条件下。蒸馏后可以以高收率分离相应的烷基乳酸酯,这使得可以从痕量的相应乳酸酯中分离。已经确定,AlCl 3与醇反应,同时产生HCl和Al醇盐配合物(如11),它们都是丙交酯醇解的催化活性物质。

更新日期:2017-12-19
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