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Triphenyltin derivatives of sulfanylcarboxylic esters
Journal of Inorganic Biochemistry ( IF 3.8 ) Pub Date : 2017-12-20 , DOI: 10.1016/j.jinorgbio.2017.12.009
José S. Casas , María D. Couce , Agustín Sánchez , Rafael Seoane , José Sordo , Antonio Perez-Estévez , Ezequiel Vázquez-López

The reaction of 3-(aryl)-2-sulfanylpropenoic acids [H2xspa; x: p = 3-phenyl-, f = 3-(2-furyl)-, t = 3-(2-thienyl)-] with methanol or ethanol gave the corresponding methyl (Hxspme) or ethyl (Hxspee) esters. The reaction of these esters (HL) with triphenyltin(IV) hydroxide gave compounds of the type [SnPh3L], which were isolated and characterized as solids by elemental analysis, IR spectroscopy and mass spectrometry and in solution by multinuclear (1H, 13C and 119Sn) NMR spectroscopy. The structures of [SnPh3(pspme)], [SnPh3(fspme)] and [SnPh3(fspee)] were determined by X-ray diffractometry and the antimicrobial activity against E. coli, S. aureus, B. subtilis, P. aeruginosa, Resistant P. aeruginosa (a strain resistant to ‘carbapenem’), and C. albicans was tested and the in vitro cytotoxic activity against the HeLa-229, A2780 and A2780cis cell lines was determined for all compounds.



中文翻译:

硫烷基羧酸酯的三苯基锡衍生物

3-(芳基)-2-硫烷基丙二酸的反应[H 2 x spa;m / z]Xp  = 3苯基,F = 3-(2-呋喃基) - , - = 3-(2-噻吩基) - ]与甲醇或乙醇,得到相应的甲基(H X SPME)或乙基(H X SPEE )酯。这些酯(HL)与氢氧化三苯基锡(IV)的反应生成了[SnPh 3 L]类型的化合物,通过元素分析,红外光谱和质谱分析对它们进行了分离和表征为固体,并在溶液中通过多核(1 H,13 C和119 Sn)NMR光谱。[SnPh 3(pspme)],[SnPh 3[fspme]和[SnPh 3(fspee)]通过X射线衍射法测定,并且对大肠杆菌金黄色葡萄球菌枯草芽孢杆菌铜绿假单胞菌抗性铜绿假单胞菌(对'碳青霉烯“),和白色念珠菌测试和体外对抗的HeLa-229的细胞毒性活性,A2780和A2780测定所有化合物的细胞系。

更新日期:2017-12-20
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