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Diterpenoids from the fruits of Rhododendron molle, potent analgesics for acute pain
Tetrahedron ( IF 2.1 ) Pub Date : 2017-12-20 , DOI: 10.1016/j.tet.2017.12.017
Yong Li , Yu-Xun Zhu , Zhao-Xin Zhang , Yang-Lan Liu , Yun-bao Liu , Jing Qu , Shuang-Gang Ma , Xiao-Jing Wang , Shi-Shan Yu

Rhododendron molle G. Don is one of the most potent traditional Chinese medicines for pain relief. Prior investigations have shown that Rhododendrons are rich sources of terpenoids. In our continuing efforts to identify structurally unique and biologically interesting diterpenoids, the fruits of R. molle were collected from Guangxi Province. A chemical study was carried out on the EtOH extract, which led to the isolation of 18 diterpenoids including 12 new compounds. The isolation and structural elucidation of new compounds 112, as well as the evaluation of the antinociceptive activities of these compounds were reported.



中文翻译:

杜鹃花果实中的二萜类化合物,用于急性疼痛的有效止痛药

杜鹃花杜鹃是最有效的止痛中药之一。先前的研究表明杜鹃花是萜类化合物的丰富来源。在我们不断努力确定结构独特且生物学上有趣的二萜类化合物的过程中,R。molle的果实采自广西省。对EtOH提取物进行了化学研究,分离出18种二萜类化合物,其中包括12种新化合物。分离和新化合物的结构解析1 - 12进行了报道,以及这些化合物的镇痛活性的评估。

更新日期:2017-12-20
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