PLOS Biology ( IF 7.8 ) Pub Date : 2017-12-19 , DOI: 10.1371/journal.pbio.2002800 Joseph M Braun 1 , Kimberly Gray 2
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Epidemiological studies play an important role in quantifying how early life environmental chemical exposures influence the risk of childhood diseases. These studies face at least four major challenges that can produce noise when trying to identify signals of associations between chemical exposure and childhood health. Challenges include accurately estimating chemical exposure, confounding from causes of both exposure and disease, identifying periods of heightened vulnerability to chemical exposures, and determining the effects of chemical mixtures. We provide recommendations that will aid in identifying these signals with more precision.
中文翻译：
研究早期环境化学暴露对儿童健康的健康影响的挑战
流行病学研究在量化早期环境化学暴露如何影响儿童疾病风险方面发挥着重要作用。这些研究在试图识别化学品暴露与儿童健康之间的关联信号时，至少面临四个可能产生噪音的主要挑战。挑战包括准确估计化学暴露，混淆暴露和疾病的原因，确定对化学暴露的高度脆弱性时期，以及确定化学混合物的影响。我们提供的建议将有助于更准确地识别这些信号。
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