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Human Immunodeficiency Virus Antiretroviral Resistance and Transmission in Mother-Infant Pairs Enrolled in a Large Perinatal Study.
Clinical Infectious Diseases ( IF 8.2 ) Pub Date : 2017-12-19 , DOI: 10.1093/cid/cix1104
Nava Yeganeh 1 , Tara Kerin 1 , Bonnie Ank 1 , D Heather Watts 2 , Margaret Camarca 3 , Esau C Joao 4 , Jose Henrique Pilotto 5, 6 , Valdilea G Veloso 7 , Yvonne Bryson 1 , Glenda Gray 8 , Gerhard Theron 9 , Ruth Dickover 1 , Mariza G Morgado 10 , Breno Santos 11 , Regis Kreitchmann 12 , Lynne Mofenson 13 , Karin Nielsen-Saines 1
Affiliation  

The presence of antiretroviral drug-associated resistance mutations (DRMs) may be particularly problematic in human immunodeficiency virus (HIV)–infected pregnant women as it can lead to mother-to-child transmission (MTCT) of resistant HIV strains. This study evaluated the prevalence and the effect of antiretroviral DRMs in previously untreated mother-infant pairs.

中文翻译:

一项大型围产期研究中的人类免疫缺陷病毒抗逆转录病毒耐药性和母婴对传播。

抗逆转录病毒药物相关耐药性突变(DRM)的存在在感染人类免疫缺陷病毒(HIV)的孕妇中可能尤其成问题,因为它可以导致耐药HIV菌株的母婴传播(MTCT)。这项研究评估了以前未接受过治疗的母婴对中抗逆转录病毒DRM的患病率和效果。
更新日期:2017-12-19
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