Ivacaftor is a potentiator of the cystic fibrosis transmembrane conductance regulator (CFTR) that reduces Pseudomonas aeruginosa culture positivity in CF patients with unclear mechanisms. Riquelme et al. (2017) propose that improved CFTR trafficking could enhance P. aeruginosa clearance through activating the tumor suppressor PTEN.

中文翻译：

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强化CFTR以获得抗微生物免疫力

Ivacaftor是囊性纤维化跨膜电导调节剂（CFTR）的增强剂，可降低机制不明的CF患者中的铜绿假单胞菌培养阳性。Riquelme等。（2017）提出改进的CFTR转运可以通过激活肿瘤抑制因子PTEN来增强铜绿假单胞菌的清除率。