The regulatory mechanisms governing T cell exhaustion remain incompletely understood. Man et al. (2017) and Wu et al. (2017) report that the T cell receptor responsive transcription factor Irf4 promotes T cell exhaustion in chronic viral infection but dampens exhaustion in response to tissue allografts.

中文翻译：

---

感觉筋疲力尽？调优Irf4激活功能异常的T细胞

关于T细胞衰竭的调节机制仍未完全了解。Man等。（2017）和Wu等。（2017）报告说，T细胞受体响应转录因子Irf4在慢性病毒感染中促进T细胞衰竭，但对同种异体移植的反应会抑制疲劳。