The gut contents shape intestinal immune homeostasis, a phenomenon best documented for microbiota-immune interactions. In this issue of Immunity, Cao et al. (2017) show that bile acids trigger T cell-mediated inflammation at their site of active absorption in the ileum, unless cells are protected by the membrane transporter Mdr1.

中文翻译：

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Mdr1从胆汁中拯救T细胞

肠道内容物可形成肠道免疫稳态，这是微生物与免疫相互作用最能证明的现象。在本期《免疫》中，曹等人。（2017）显示胆汁酸会在回肠的主动吸收部位触发T细胞介导的炎症，除非细胞受到膜转运蛋白Mdr1的保护。