Type-2-cell-mediated immune responses play a critical role in mediating both host-resistance and disease-tolerance mechanisms during helminth infections. Recently, type 2 cell responses have emerged as major regulators of tissue repair and metabolic homeostasis even under steady-state conditions. In this review, we consider how studies of helminth infection have contributed toward our expanding cellular and molecular understanding of type-2-cell-mediated immunity, as well as new areas such as the microbiome. By studying how these successful parasites form chronic infections without overt pathology, we are gaining additional insights into allergic and inflammatory diseases, as well as normal physiology.

2型细胞介导的免疫反应在蠕虫感染过程中介导宿主抗性和疾病耐受机制中起着关键作用。最近，即使在稳态条件下，2型细胞应答也已成为组织修复和代谢稳态的主要调节剂。在这篇综述中，我们考虑了蠕虫感染的研究如何促进我们对2型细胞介导的免疫以及新领域（例如微生物组）的细胞和分子理解的扩展。通过研究这些成功的寄生虫如何在没有明显病理的情况下形成慢性感染，我们获得了对变态反应和炎性疾病以及正常生理的更多见解。