Aminoglycoside antibiotics are known toxins to cochlear hair cells, causing permanent hearing loss. Using the zebrafish lateral line system as a platform for drug screen and subsequent validation in the rat cochlea in vivo, Chowdhury et al. characterized a novel otoprotectant working against aminoglycoside-induced hearing loss.

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注意您的耳朵：氨基糖苷毒性的新解药？

氨基糖苷类抗生素是已知的耳蜗毛细胞毒素，会导致永久性听力损失。Chowdhury等人使用斑马鱼侧线系统作为药物筛选和随后在大鼠耳蜗体内进行验证的平台。表征了一种新型的耳保护剂，可对抗氨基糖苷类引起的听力损失。