Amplified detection of genome-containing biological targets using terminal deoxynucleotidyl transferase-assisted rolling circle amplification,Chemical Communications

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Amplified detection of genome-containing biological targets using terminal deoxynucleotidyl transferase-assisted rolling circle amplification
Chemical Communications ( IF 4.3 ) Pub Date : 2017-12-19 00:00:00 , DOI: 10.1039/c7cc09337c
Yi-Chen Du _{1,

2,

3,

4,

5} , Yan-Jun Zhu _{1,

2,

3,

4,

5} , Xiao-Yu Li _{1,

2,

3,

4,

5} , De-Ming Kong _{1,

2,

3,

4,

5}

Affiliation

We proposed a terminal deoxynucleotidyl transferase (TdT)-assisted rolling circle amplification (RCA) strategy for the amplified detection of genome-containing biological targets. The synergetic signal amplification of DNase I-mediated genomic DNA fragmentation and subsequent RCA allow the sensing platform to have extraordinarily high sensitivity.

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