Copper/guanidine-catalyzed asymmetric alkynylation of isatin-derived ketimines,Chemical Communications

当前位置： X-MOL 学术 › Chem. Commun. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Copper/guanidine-catalyzed asymmetric alkynylation of isatin-derived ketimines
Chemical Communications ( IF 4.3 ) Pub Date : 2017-12-19 00:00:00 , DOI: 10.1039/c7cc08920a
Quangang Chen _{1,

2,

3,

4,

5} , Lihua Xie _{1,

2,

3,

4,

5} , Zhaojing Li _{1,

2,

3,

4,

5} , Yu Tang _{1,

2,

3,

4,

5} , Peng Zhao _{1,

2,

3,

4,

5} , Lili Lin _{1,

2,

3,

4,

5} , Xiaoming Feng _{1,

2,

3,

4,

5} , Xiaohua Liu _{1,

2,

3,

4,

5}

Affiliation

Isatin-derived ketimines undergo enantioselective alkynylation reactions in the presence of copper iodide and easily accessible guanidine-amides. The corresponding 3-alkynyl-3-aminooxyindoles are obtained in up to 95% yield and 96% ee. The guanidine plays a role in the formation of copper acetylide and the enantiodetermining step and the basic additive is excluded.

中文翻译：