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Metabolic fate of strawberry polyphenols after chronic intake in healthy older adults
Food & Function ( IF 5.1 ) Pub Date : 2017-12-19 00:00:00 , DOI: 10.1039/c7fo01843f Amandeep K. Sandhu 1, 2, 3, 4 , Marshall G. Miller 4, 5, 6 , Nopporn Thangthaeng 4, 5, 6 , Tammy M. Scott 4, 5, 6 , Barbara Shukitt-Hale 4, 5, 6 , Indika Edirisinghe 1, 2, 3, 4 , Britt Burton-Freeman 1, 2, 3, 4, 7
Food & Function ( IF 5.1 ) Pub Date : 2017-12-19 00:00:00 , DOI: 10.1039/c7fo01843f Amandeep K. Sandhu 1, 2, 3, 4 , Marshall G. Miller 4, 5, 6 , Nopporn Thangthaeng 4, 5, 6 , Tammy M. Scott 4, 5, 6 , Barbara Shukitt-Hale 4, 5, 6 , Indika Edirisinghe 1, 2, 3, 4 , Britt Burton-Freeman 1, 2, 3, 4, 7
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Strawberries contain a wide array of nutrients and phytochemicals including polyphenols such as anthocyanins, proanthocyanidins and ellagitannins. These polyphenols are absorbed and metabolized to various phenolic metabolites/conjugates in the body, which may play a role in disease risk reduction. In the present study, we investigated the metabolic fate of strawberry polyphenols after chronic (90 days) supplementation of freeze-dried strawberry (24 g d−1, equivalent to 2 cups of fresh strawberries) vs. control powder in 19 healthy older adults. Blood samples were collected at two time-points i.e., fasting (t = 0 h) and 2 h after the breakfast meal. On days 45 and 90 breakfast also included a control or strawberry drink consistent with their treatment randomization. A total of 21 polyphenolic metabolites were quantified in plasma consisting of 3 anthocyanins/metabolites, 3 urolithin metabolites and 15 phenolic acid metabolites. Among anthocyanins/metabolite, pelargonidin glucuronide (85.7 ± 9.0 nmol L−1, t = 2 h, day 90) was present in the highest concentration. Persistent concentrations of anthocyanins/metabolites, urolithins and some phenolic acids were observed in fasting (t = 0 h) plasma samples on day 45 and 90 after strawberry drink consumption suggesting a role of enteric, enterohepatic recycling or upregulation of gut microbial and/or human metabolism of these compounds. Our results suggest that strawberry polyphenols are absorbed and extensively metabolized, and can persist in the circulation.
中文翻译：
慢性摄入健康老年人后草莓多酚的代谢命运
草莓含有多种营养物质和植物化学物质，包括多酚，如花青素，原花青素和鞣花单宁。这些多酚在体内被吸收并代谢为各种酚类代谢物/共轭物，可能在降低疾病风险中发挥作用。在本研究中，我们调查了在19名健康老年人中长期（90天）补充冻干草莓（24 gd -1，相当于2杯新鲜草莓）与对照粉后草莓多酚的代谢命运。在两个时间点即空腹（t= 0小时）和早餐后2小时。在第45天和第90天，早餐还包括对照或草莓饮料，与他们的治疗随机分组一致。血浆中总共定量了21种多酚代谢物，其中包括3种花色素苷/代谢物，3种尿石素代谢物和15种酚酸代谢物。在花色苷/代谢产物中，pelargonidin葡萄糖醛酸苷（85.7±9.0 nmol L -1，t = 2 h，第90天）以最高浓度存在。空腹时观察到花青素/代谢产物，尿石素和某些酚酸的持续浓度（t= 0 h）饮用草莓饮料后第45天和90天的血浆样品表明这些化合物具有肠道，肠肝循环或肠道微生物和/或人体代谢上调的作用。我们的结果表明草莓多酚被吸收并广泛代谢，并且可以在循环中持续存在。
更新日期：2017-12-19
中文翻译：
慢性摄入健康老年人后草莓多酚的代谢命运
草莓含有多种营养物质和植物化学物质，包括多酚，如花青素，原花青素和鞣花单宁。这些多酚在体内被吸收并代谢为各种酚类代谢物/共轭物，可能在降低疾病风险中发挥作用。在本研究中，我们调查了在19名健康老年人中长期（90天）补充冻干草莓（24 gd -1，相当于2杯新鲜草莓）与对照粉后草莓多酚的代谢命运。在两个时间点即空腹（t= 0小时）和早餐后2小时。在第45天和第90天，早餐还包括对照或草莓饮料，与他们的治疗随机分组一致。血浆中总共定量了21种多酚代谢物，其中包括3种花色素苷/代谢物，3种尿石素代谢物和15种酚酸代谢物。在花色苷/代谢产物中，pelargonidin葡萄糖醛酸苷（85.7±9.0 nmol L -1，t = 2 h，第90天）以最高浓度存在。空腹时观察到花青素/代谢产物，尿石素和某些酚酸的持续浓度（t= 0 h）饮用草莓饮料后第45天和90天的血浆样品表明这些化合物具有肠道，肠肝循环或肠道微生物和/或人体代谢上调的作用。我们的结果表明草莓多酚被吸收并广泛代谢，并且可以在循环中持续存在。
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