There has recently been an increased interest in active pharmaceutical agents and various other molecules that contain the 1, 1‐diaryl stereocenter. This has led to the development of novel synthetic strategies to access molecules having this structural moiety. The current Review describes the variety of synthetic methodologies available for the enantioselective synthesis of 1, 1‐diarylethanes, triarylmethanes and related molecules with a 1, 1‐diaryl stereogenic center that were reported since 1995. The prime focus of the Review is on the formation of the 1, 1‐diarylmethine stereocenter either through the use of various enantioselective processes using chiral catalysts (the asymmetric catalytic approach) or through the use of chiral substrates and achiral catalysts. Resolution of racemic substrates is also required for the synthesis of this chiral molecule, but this approach is not covered in this Review. Moreover, comparative discussions on the future aspects of the synthesis of these molecules with a short comparison of the different available routes and possible areas of development are also presented.

中文翻译：

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1,2-二芳基烷烃，三芳基甲烷和含二芳基次甲基立体中心的相关分子的对映选择性合成的最新策略概述

最近，人们对活性药物和其他各种含有1，1-二芳基立体中心的分子的兴趣日益增加。这导致开发出新颖的合成策略以接近具有该结构部分的分子。本综述描述了自1995年以来可用于对映选择性合成1,1,1-二芳基乙烷，三芳基甲烷和具有1,1,1-二芳基立体中心的相关分子的多种合成方法。通过使用手性催化剂的各种对映选择性工艺（不对称催化方法）或通过使用手性底物和非手性催化剂，可以得到1，1-二芳基次甲基的立体中心。该手性分子的合成也需要外消旋底物的拆分，但是该方法未在本综述中涵盖。此外，还提出了关于这些分子合成的未来方面的比较讨论，并简短比较了不同的可用途径和可能的发展领域。