Next-Generation DNA-Functionalized Quantum Dots as Biological Sensors,ACS Chemical Biology

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Next-Generation DNA-Functionalized Quantum Dots as Biological Sensors
ACS Chemical Biology ( IF 3.5 ) Pub Date : 2017-12-19 00:00:00 , DOI: 10.1021/acschembio.7b00887
Ganglin Wang ₁ , Zhi Li ₁ , Nan Ma ₁

Affiliation

DNA-functionalized quantum dots (DNA-QDs) have found considerable application in biosensing and bioimaging. Different from the first generation (I-G) DNA-QDs prepared via conventional bioconjugation chemistry, the second generation (II-G) DNA-QDs prepared via one-step DNA-templated QD synthesis features a defined number of DNA valencies (usually monovalency), which is preferable for controlled assembly and biological targeting. In this review, we summarize recent progress in designing QD probes based on II-G DNA-QDs for advanced sensing and imaging applications. It opens up new avenues for highly sensitive and intelligent sensing of a range of disease-relevant biomolecules in vitro and in living cells.

中文翻译：

下一代DNA功能化量子点作为生物传感器。

DNA功能化的量子点（DNA-QD）已在生物传感和生物成像中获得大量应用。与通过常规生物共轭化学制备的第一代（IG）DNA-QD不同，通过一步式DNA模板QD合成制备的第二代（II-G）DNA- QD具有一定数量的DNA价数（通常为单价），对于受控的装配和生物靶向而言，这是首选。在这篇综述中，我们总结了基于II-G DNA-QD设计用于高级传感和成像应用的QD探针的最新进展。它为在体外和活细胞中对一系列与疾病相关的生物分子进行高度灵敏和智能感应开辟了新途径。

更新日期：2017-12-19

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