PXR as a mediator of herb–drug interaction,Journal of Food and Drug Analysis

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PXR as a mediator of herb–drug interaction
Journal of Food and Drug Analysis ( IF 2.6 ) Pub Date : 2018-04-01 , DOI: 10.1016/j.jfda.2017.11.007
Brett C Hogle ₁ , Xiudong Guan ₂ , M Maggie Folan ₁ , Wen Xie ₃

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Medicinal herbs have been a part of human medicine for thousands of years. The herb-drug interaction is an extension of drug-drug interaction, in which the consumptions of herbs cause alterations in the metabolism of drugs the patients happen to take at the same time. The pregnane X receptor (PXR) has been established as one of the most important transcriptional factors that regulate the expression of phase I enzymes, phase II enzymes, and drug transporters in the xenobiotic responses. Since its initial discovery, PXR has been implicated in multiple herb-drug interactions that can lead to alterations of the drug's pharmacokinetic properties and cause fluctuating therapeutic efficacies, possibly leading to complications. Regions of the world that heavily incorporate herbalism into their primary health care and people turning to alternative medicines as a personal choice could be at risk for adverse reactions or unintended results from these interactions. This article is intended to highlight our understanding of the PXR-mediated herb-drug interactions.

中文翻译：

PXR 作为草药-药物相互作用的介质

数千年来，草药一直是人类医学的一部分。草药相互作用是药物相互作用的延伸，其中草药的消耗导致患者恰好同时服用的药物代谢发生改变。孕烷 X 受体 (PXR) 已被确定为最重要的转录因子之一，可调节异生反应中 I 期酶、II 期酶和药物转运蛋白的表达。自最初发现以来，PXR 与多种草药-药物相互作用有关，这些相互作用可能导致药物的药代动力学特性发生改变，并导致治疗效果波动，可能导致并发症。世界上大量将草药学纳入其初级卫生保健的地区以及将替代药物作为个人选择的人们可能会因这些相互作用而面临不良反应或意外结果的风险。本文旨在强调我们对 PXR 介导的草药-药物相互作用的理解。

更新日期：2018-04-01

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