The actual coagulation status may be reliably measured using only highly sensitive global functional tests; however, they are not numerous and all of them have disadvantages. Thrombodynamics (TD), a novel global coagulation test, is sensitive to hypo- and hypercoagulable states. The main properties of this test were investigated, and its capabilities for hemostasis analysis were verified through pharmacodynamic monitoring of the most widely used anticoagulants, heparins. The anticoagulant effects in the plasma of donors (n = 20) and patients after hip replacement (n = 20) spiked with unfractionated heparin or enoxaparin were measured in vitro to eliminate the influence of pharmacokinetic factors. Sensitivity for heparins was compared for activated partial thromboplastin time, thrombin generation tests and TD. TD was shown to reliably characterize the pharmacodynamics of any heparin in the entire range of its prophylactic and therapeutic concentrations. Inter-individual variability for the anticoagulant action of heparins was also calculated using the TD data. This variability did not differ between the investigated groups and did not exceed 12% and 20% for the stationary clot growth rate in the presence of unfractionated heparin and enoxaparin, respectively. That finding was in accordance with the values determined earlier using the thrombin generation test. The study results showed that TD has advantages over the other global methods of coagulation analysis. These advantages are good standardization, high reproducibility, independence of the parameter values from patient age and gender, and a narrower parameter distribution in a normal population. These results indicate that TD is a promising universal assessment method that improves the quality of hemostasis analysis because it more reliably detects deviations from the parameters' reference values.

仅使用高度敏感的整体功能测试可以可靠地测量实际的凝结状态；但是，它们并不多，而且都有缺点。血栓动力学（TD）是一种新型的全凝试验，对低凝状态和高凝状态敏感。研究了该测试的主要特性，并通过对最广泛使用的抗凝剂肝素进行药效动力学监测，验证了其止血分析的能力。体外测定了供体血浆（n = 20）和髋关节置换术后患者（n = 20）血浆中未添加普通肝素或依诺肝素的抗凝作用，以消除药代动力学因素的影响。比较了活化的部分凝血活酶时间，凝血酶生成测试和TD对肝素的敏感性。TD已被证明可以在预防和治疗浓度的整个范围内可靠地表征任何肝素的药效学。还使用TD数据计算了肝素抗凝作用的个体间差异。在研究组之间，这种变异性没有差异，并且在存在普通肝素和依诺肝素的情况下，静止血块的增长率分别不超过12％和20％。该发现与先前使用凝血酶生成测试确定的值一致。研究结果表明，TD具有优于其他整体凝血分析方法的优势。这些优点是标准化好，可重复性高，参数值不受患者年龄和性别的影响以及在正常人群中参数分布更窄。