High Antifungal Activity against Candida Species of Monometallic and Bimetallic Nanoparticles Synthesized in Nanoreactors,ACS Biomaterials Science & Engineering

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High Antifungal Activity against Candida Species of Monometallic and Bimetallic Nanoparticles Synthesized in Nanoreactors
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2018-01-04 00:00:00 , DOI: 10.1021/acsbiomaterials.7b00511
Jorge A. Gutiérrez ₁ , Silvia Caballero ₁ , Laura A. Díaz ₁ , M. Alejandra Guerrero ₁ , Jennifer Ruiz ₂ , Claudia C. Ortiz ₂

Affiliation

Among all novel challenges nowadays worldwide, infectious disease is probably one of the most important. It is well-known that common treatments used include high doses of antibiotics, which are very invasive therapies for patients. These treatments are more intensive when the infection is related to multidrug resistant microorganisms. In this sense, in this work we report the use of reverse micelles to form less than 5 nm gold, silver, and gold–silver nanoparticles (NPs) with biological activity against five opportunistic Candida strains responsible of several diseases in human beings. As a result, we evaluate the interface properties and droplet–droplet interactions of micelles founding high fluidity in the polar head of the surfactant, necessary to form a flexible interaction channel in the “dimmer” micelle–micelle. In this condition, we form monodispersed, highly reactive NPs with sizes less than 5 nm with high antifungal activity against C. parapsilosis, C. Krusei, C. glabrata, C. guillermondii, and C. albicans, with minimum inhibitory concentrations (MIC₅₀) less than 0.7 ppm in all cases, the lowest reported to the best of our knowledge. These are very promising results to develop alternative therapies to treat fungal diseases in humans, animals, and plants, or to coat conventional surfaces in surgery rooms.

中文翻译：

纳米反应器中合成的单金属和双金属纳米颗粒念珠菌物种的高抗真菌活性。

在当今世界范围内所有新颖的挑战中，传染病可能是最重要的挑战之一。众所周知，常用的治疗方法包括高剂量的抗生素，这对患者而言是非常具有侵入性的疗法。当感染与多药耐药性微生物有关时，这些治疗将更加密集。从这个意义上讲，在这项工作中，我们报告了使用反胶束形成小于5 nm的金，银和金银纳米颗粒（NPs），其具有针对五个机会性念珠菌的生物活性。引起人类几种疾病的菌株。结果，我们评估了在表面活性剂极性头中发现高流动性的胶束的界面性质和液滴-液滴相互作用，这对于在“较暗的”胶束-胶束中形成灵活的相互作用通道是必不可少的。在这种条件下，我们形成尺寸小于5 nm的单分散，高反应性NP，具有对C. parapsilosis，C。Krusei，C。glabrata，C。guillermondii和C. albicans的高抗真菌活性，并具有最低抑制浓度（MIC ₅₀）在所有情况下均低于0.7 ppm，据我们所知，最低的报告值。这些都是非常有希望的结果，可以开发出替代疗法来治疗人类，动物和植物中的真菌疾病，或在手术室中覆盖常规表面。

更新日期：2018-01-04

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