Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2017-12-19 , DOI: 10.1016/j.bmcl.2017.12.039 Jinlian Zhao , Jiamin Feng , Zhen Tan , Jimei Liu , Min Zhang , Ridao Chen , Kebo Xie , Dawei Chen , Yan Li , Xiaoguang Chen , Jungui Dai
Bistachybotrysins A–C (1–3), three phenylspirodrimane dimers representing an unusual [6,6,7,6]-tetracyclic skeleton with a central 2,10-dioxabicyclo[4.3.1]decan-7-ol core fused with two phenyl units, were isolated from a fungal strain, Stachybotrys chartarum CGMCC 3.5365. The structures of 1–3 were elucidated through extensive spectroscopic data analysis, including Mo2(AcO)4-induced and calculated electronic circular dichroism (ECD). 1 and 2 exhibited potent cytotoxicity against four human tumor cell lines with IC50 values in the range of 2.8–7.5 μM. Furthermore, a possible biogenesis for 1–3 is proposed.
中文翻译:
Bistachybotrysins A–C,三个苯基螺旋嘧啶二聚体,来自沙丁鱼(Stachybotrys chartarum)具有细胞毒性
Bistachybotrysins A-C(1 - 3),表示与中央-2,10-二氧杂双环[4.3.1]癸-7-醇芯一个不寻常的[6,6,7,6] -tetracyclic骨架3个phenylspirodrimane二聚体融合有两个从真菌菌株Stachybotrys chartarum CGMCC 3.5365中分离出苯基单元。的结构1 - 3分别通过广泛的光谱数据分析阐明,含有Mo 2(ACO)4诱导的和计算的电子圆二色性(ECD)。1和2对具有IC 50的四种人类肿瘤细胞系表现出强力的细胞毒性值在2.8–7.5μM的范围内。此外,对于可能的生物合成1 - 3提出。