A CO-free palladium-catalyzed cyclizative carbonylation of 2-benzylpyridines was developed, leading to pyridoisoquinolinones. This procedure proceeded with the sequential carbonylation of the ortho-C–H bond and the dearomative C–N bond formation. The combination of acetic anhydride and formic acid rather than toxic CO gas was employed in this reaction. The ortho-C–H palladation intermediate palladacycle, which showed comparable activity during this reaction, was well characterized. Notably, N-phenyl-2-pyridinamine also worked well to provide 11H-pyrido[2,1-b]quinazolin-11-one.

中文翻译：

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钯催化的2-苄基吡啶的无CO环化羰基化反应生成吡啶基异喹啉酮†

开发了一种无CO的2-苄基吡啶钯催化环化羰基化反应，从而生成吡啶基异喹啉酮。该过程先进行邻-C-H键的顺序羰基化和脱芳香性C-N键的形成。在该反应中使用乙酸酐和甲酸的组合而不是有毒的CO气体。很好地表征了在此反应过程中表现出可比活性的邻-C–H palpalation中间体帕拉达环。值得注意的是，N-苯基-2-吡啶胺也很好地提供了11 H-吡啶并[ 2,1- b ]喹唑啉-11-一。