Application of ω-Transaminases in the Pharmaceutical Industry,Chemical Reviews

当前位置： X-MOL 学术 › Chem. Rev. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Application of ω-Transaminases in the Pharmaceutical Industry
Chemical Reviews ( IF 51.4 ) Pub Date : 2017-12-18 00:00:00 , DOI: 10.1021/acs.chemrev.7b00437
Stephen A. Kelly ₁ , Stefan Pohle ₂ , Scott Wharry ₂ , Stefan Mix ₂ , Christopher C.R. Allen ₃ , Thomas S. Moody _{2,

4} , Brendan F. Gilmore ₁

Affiliation

Chiral amines are valuable building blocks for the pharmaceutical industry. ω-TAms have emerged as an exciting option for their synthesis, offering a potential “green alternative” to overcome the drawbacks associated with conventional chemical methods. In this review, we explore the application of ω-TAms for pharmaceutical production. We discuss the diverse array of reactions available involving ω-TAms and process considerations of their use in both kinetic resolution and asymmetric synthesis. With the aid of specific drug intermediates and APIs, we chart the development of ω-TAms using protein engineering and their contribution to elegant one-pot cascades with other enzymes, including carbonyl reductases (CREDs), hydrolases and monoamine oxidases (MAOs), providing a comprehensive overview of their uses, beginning with initial applications through to the present day.

中文翻译：

ω-转氨酶在制药行业中的应用

手性胺是制药业的重要组成部分。ω-TAms已成为其合成的令人兴奋的选择，它提供了一种潜在的“绿色替代品”，以克服常规化学方法带来的弊端。在这篇综述中，我们探索了ω-TAms在药物生产中的应用。我们讨论了可用的涉及ω-TAms的各种反应，以及它们在动力学拆分和不对称合成中使用的工艺考虑。借助特定的药物中间体和API，我们利用蛋白质工程技术绘制了ω-TAms的发展图，以及它们与其他酶（包括羰基还原酶（CRED），水解酶和单胺氧化酶（MAO））在优雅的一锅级联反应中的作用，从而提供对其用途的全面概述，

更新日期：2017-12-18

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11