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Application of ω-Transaminases in the Pharmaceutical Industry
Chemical Reviews ( IF 51.4 ) Pub Date : 2017-12-18 00:00:00 , DOI: 10.1021/acs.chemrev.7b00437
Stephen A. Kelly 1 , Stefan Pohle 2 , Scott Wharry 2 , Stefan Mix 2 , Christopher C.R. Allen 3 , Thomas S. Moody 2, 4 , Brendan F. Gilmore 1
Affiliation  

Chiral amines are valuable building blocks for the pharmaceutical industry. ω-TAms have emerged as an exciting option for their synthesis, offering a potential “green alternative” to overcome the drawbacks associated with conventional chemical methods. In this review, we explore the application of ω-TAms for pharmaceutical production. We discuss the diverse array of reactions available involving ω-TAms and process considerations of their use in both kinetic resolution and asymmetric synthesis. With the aid of specific drug intermediates and APIs, we chart the development of ω-TAms using protein engineering and their contribution to elegant one-pot cascades with other enzymes, including carbonyl reductases (CREDs), hydrolases and monoamine oxidases (MAOs), providing a comprehensive overview of their uses, beginning with initial applications through to the present day.

中文翻译:

ω-转氨酶在制药行业中的应用

手性胺是制药业的重要组成部分。ω-TAms已成为其合成的令人兴奋的选择,它提供了一种潜在的“绿色替代品”,以克服常规化学方法带来的弊端。在这篇综述中,我们探索了ω-TAms在药物生产中的应用。我们讨论了可用的涉及ω-TAms的各种反应,以及它们在动力学拆分和不对称合成中使用的工艺考虑。借助特定的药物中间体和API,我们利用蛋白质工程技术绘制了ω-TAms的发展图,以及它们与其他酶(包括羰基还原酶(CRED),水解酶和单胺氧化酶(MAO))在优雅的一锅级联反应中的作用,从而提供对其用途的全面概述,
更新日期:2017-12-18
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