Effects of Additives on the Morphology of Thiamine Nitrate: The Great Difference of Two Kinds of Similar Additives,Crystal Growth & Design

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Effects of Additives on the Morphology of Thiamine Nitrate: The Great Difference of Two Kinds of Similar Additives
Crystal Growth & Design ( IF 3.2 ) Pub Date : 2018-01-02 00:00:00 , DOI: 10.1021/acs.cgd.7b01202
Dandan Han _{1,

2} , Bo Yu _{1,

2} , Yumin Liu _{1,

2} , Shichao Du _{1,

2} , Sohrab Rohani ₃ , Teng Zhang _{1,

2} , Shiyuan Liu _{1,

2} , Peng Shi _{1,

2} , Haisheng Wang _{1,

2} , Lina Zhou _{1,

2} , Junbo Gong _{1,

2,

4}

Affiliation

The growth of thiamine nitrate, in supersaturated aqueous solutions in the absence and presence of sodium alkyl sulfates CH₃(CH₂)_nSO₄Na and sodium alkyl sulfonates CH₃(CH₂)_nSO₃Na was studied by a single seed crystal growth experiment. It was surprisingly found that the growth of the a-axis of thiamine nitrate is significantly inhibited by CH₃(CH₂)_nSO₄Na, thus reducing the aspect ratio of thiamine nitrate, while the aspect ratio of thiamine nitrate in the presence of CH₃(CH₂)_nSO₃Na remains almost constant. Furthermore, the mechanism of additives to modify the crystal morphology is proposed: both additives can inhibit the growth of thiamine nitrate by hindering the solute diffusion. However, their unusual behavior is due to the selective adsorption, which was caused by electrostatic and hydrogen bond interactions between solute and additive molecules. In particular, the anionic groups exposed at the end of the additives demonstrate an interesting case in which a small variation in the charge density and hydrogen bonding ability can lead to a marked difference in modifying the crystal growth behavior. The results obtained from this study should be helpful in the performance evaluation and selection of the morphology modifiers for thiamine nitrate crystals.

中文翻译：

添加剂对硫胺素硝酸盐形态的影响：两种相似添加剂的巨大差异

通过单晶种研究了在不存在和存在烷基硫酸钠硫酸钠CH ₃（CH ₂）_n SO ₄ Na和烷基磺酸钠CH ₃（CH ₂）_n SO ₃ Na的情况下在过饱和水溶液中硫胺素硝酸盐的生长。生长实验。令人惊讶地发现，CH ₃（CH ₂）_n SO ₄ Na极大地抑制了硝酸硫胺素的α轴的生长，从而降低了硝酸硫胺素的长径比，而在存在硫胺素的情况下硝酸硫胺素的长径比。通道₃（CH₂）_Ñ SO ₃Na几乎保持不变。此外，提出了添加剂改变晶体形态的机理：两种添加剂都可以通过阻碍溶质的扩散来抑制硝酸硫胺素的生长。然而，它们的不寻常行为是由于选择性吸附，这是由于溶质和添加剂分子之间的静电和氢键相互作用引起的。特别地，在添加剂的末端暴露的阴离子基团显示出有趣的情况，其中电荷密度和氢键合能力的小变化可导致在改变晶体生长行为方面的显着差异。从这项研究中获得的结果应有助于性能评估和硫胺素硝酸盐晶体的形态改性剂的选择。

更新日期：2018-01-02

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