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Voltammetric Characterisation of Anticancer Drug Irinotecan
Electroanalysis ( IF 2.7 ) Pub Date : 2017-12-18 , DOI: 10.1002/elan.201700593 Ivana Novak Jovanović 1 , Šebojka Komorsky-Lovrić 2 , Ana Lucić Vrdoljak 1 , Aleksandar R. Popović 3 , Marijana Neuberg 4
Electroanalysis ( IF 2.7 ) Pub Date : 2017-12-18 , DOI: 10.1002/elan.201700593 Ivana Novak Jovanović 1 , Šebojka Komorsky-Lovrić 2 , Ana Lucić Vrdoljak 1 , Aleksandar R. Popović 3 , Marijana Neuberg 4
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Electrochemical reduction of irinotecan was investigated on a static mercury drop electrode using square-wave voltammetry. The mechanism of irinotecan electroreduction is a complex, pH- dependent, quasireversible process and includes the transfer of two electrons and two protons. In acidic medium, the first electron transfer reaction is followed by the chemical reaction, and the product of this chemical reaction undergoes further electrochemical reduction at more negative potentials. Both irinotecan and the product of its reduction adsorb on the mercury electrode surface. Based on the adsorptive character of irinotecan, a new adsorptive stripping square-wave voltammetric method for its electroanalytical determination has been proposed. The voltammetric response could be used to determine irinotecan in the concentration range from 1×10−7 mol/L to 1.5×10−6 mol/L and from 5×10−9 mol/L to 1.2×10−7 mol/L, if the accumulation time is 20 s and 300 s, respectively. The calculated limit of detection for irinotecan was found to be 8.7×10−9 mol/L (if tacc=300 s).
中文翻译：
抗癌药物伊立替康的伏安表征
使用方波伏安法在静态汞滴电极上研究伊立替康的电化学还原。伊立替康电还原的机制是一个复杂的、pH 依赖性的、准可逆的过程，包括两个电子和两个质子的转移。在酸性介质中，第一个电子转移反应之后是化学反应，该化学反应的产物在更负的电位下进行进一步的电化学还原。伊立替康及其还原产物都吸附在汞电极表面。基于伊立替康的吸附特性，提出了一种新的吸附溶出方波伏安法测定其电分析。伏安响应可用于确定浓度范围为 1×10−7 mol/L 到 1 的伊立替康。5×10-6 mol/L 和从 5×10-9 mol/L 到 1.2×10-7 mol/L，如果累积时间分别为 20 s 和 300 s。计算得出的伊立替康检测限为 8.7×10-9 mol/L（如果 tacc=300 s）。
更新日期：2017-12-18
中文翻译：
抗癌药物伊立替康的伏安表征
使用方波伏安法在静态汞滴电极上研究伊立替康的电化学还原。伊立替康电还原的机制是一个复杂的、pH 依赖性的、准可逆的过程，包括两个电子和两个质子的转移。在酸性介质中，第一个电子转移反应之后是化学反应，该化学反应的产物在更负的电位下进行进一步的电化学还原。伊立替康及其还原产物都吸附在汞电极表面。基于伊立替康的吸附特性，提出了一种新的吸附溶出方波伏安法测定其电分析。伏安响应可用于确定浓度范围为 1×10−7 mol/L 到 1 的伊立替康。5×10-6 mol/L 和从 5×10-9 mol/L 到 1.2×10-7 mol/L，如果累积时间分别为 20 s 和 300 s。计算得出的伊立替康检测限为 8.7×10-9 mol/L（如果 tacc=300 s）。
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