Therapeutic Considerations and Conjugated Polymer‐Based Photosensitizers for Photodynamic Therapy,Macromolecular Rapid Communications

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Therapeutic Considerations and Conjugated Polymer‐Based Photosensitizers for Photodynamic Therapy
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2017-12-18 , DOI: 10.1002/marc.201700614
Zihui Meng ₁ , Weiying Hou ₂ , Hua Zhou ₂ , Libo Zhou ₂ , Haobin Chen ₂ , Changfeng Wu ₃

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Conjugated polymers have recently attracted a great deal of attention for applications in photodynamic therapy (PDT) because of their light‐harvesting capability, efficient energy transfer, and singlet oxygen generation properties. This review describes recent advances in PDT development, including therapeutic mechanisms of PDT in cancer treatments, light excitation methods, and especially recent advances of conjugated polyelectrolytes and conjugated polymer nanoparticles as photosensitizers. The future direction on PDT and further development of conjugated polymer photosensitizers are discussed. The aim of this review is to stimulate innovative ideas to synthesize a new generation of conjugated polymer photosensitizers and promote their translation to clinical applications of PDT.

中文翻译：

光动力疗法的治疗考虑因素和基于共轭聚合物的光敏剂

共轭聚合物由于其光收集能力，有效的能量转移和单线态氧生成特性，最近在光动力疗法（PDT）中的应用引起了广泛的关注。这篇综述描述了PDT发展的最新进展，包括PDT在癌症治疗中的治疗机制，光激发方法，尤其是共轭聚电解质和共轭聚合物纳米颗粒作为光敏剂的最新进展。讨论了PDT的未来方向以及共轭聚合物光敏剂的进一步发展。这篇综述的目的是激发创新思想，以合成新一代的共轭聚合物光敏剂，并将其转化为PDT的临床应用。

更新日期：2017-12-18

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