There are numerous extra- and intra-cellular processes involved in the production of reactive oxygen species (ROS). Augmented ROS generation can cause the damage of biomolecules such as proteins, nucleic acid and lipids. ROS act as an intracellular signaling component and is associated with various inflammatory responses, chronic arthropathies, including rheumatoid arthritis (RA). It is well documented that ROS can activate different signaling pathways having a vital importance in the patho-physiology of RA. Hence, understanding of the molecular pathways and their interaction might be advantageous in the development of novel therapeutic approaches for RA.

中文翻译：

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类风湿关节炎的氧化应激，后果和ROS介导的细胞信号转导

活性氧（ROS）的产生涉及许多细胞外和细胞内过程。ROS的产生增加会引起生物分子的破坏，例如蛋白质，核酸和脂质。ROS充当细胞内信号传导成分，并与各种炎症反应，慢性关节病（包括类风湿关节炎（RA））相关。众所周知，ROS可以激活不同的信号传导途径，这对RA的病理生理至关重要。因此，对分子途径及其相互作用的理解可能对发展RA的新型治疗方法有利。