Biodegradable pH-responsive hydrogels for controlled dual-drug release†,Journal of Materials Chemistry B

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Biodegradable pH-responsive hydrogels for controlled dual-drug release†
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-12-18 00:00:00 , DOI: 10.1039/c7tb01851g
Liang Xu _{1,

2,

3,

4,

5} , Linzi Qiu _{1,

2,

3,

4,

5} , Yang Sheng _{1,

2,

3,

4,

5} , Yixin Sun _{1,

2,

3,

4,

5} , Linhong Deng _{3,

4,

5,

6} , Xinqing Li _{5,

7,

8,

9,

10} , Mark Bradley _{11,

12,

13,

14,

15} , Rong Zhang _{1,

2,

3,

4,

5}

Affiliation

Dual-drug loaded pH-responsive hydrogels were prepared as a delivery system carrying, as exemplars, both anti-cancer and anti-bacterial agents for pH controlled drug release. The hydrogels were composed of poly(L-lactide)-co-polyethyleneglycol-co-poly(L-lactide) dimethacrylates (with various molecular weights of L-lactide oligomers) as a macromolecular crosslinker and copolymerized with acrylic acid and N-isopropylacrylamide. The biodegradability, biocompatibility and mechanical properties of the hydrogels were characterized with the hydrogels being nontoxic to cells, while showing a reversible >80% reduction in volume at pH 1.2 compared to pH 7.4. Drug release profiles showed differential release of tetracycline over doxorubicin at pH 1.2, with both drugs being released equally at pH 7.4. Biodegradability was tunable by altering the crosslinking density and pH, with the total degradation of the best gels observed within 2 weeks at pH 7.4.

中文翻译：

可生物降解的pH响应水凝胶，可控制双药释放†

制备了载有双药的pH响应水凝胶，作为传递系统，例如，带有用于控制pH值的药物释放的抗癌剂和抗菌剂。水凝胶的组成为聚（大号丙交酯） -共-polyethyleneglycol-共-聚（大号丙交酯）二甲基丙烯酸酯（具有各种分子量大号丙交酯低聚物），其为高分子交联剂和与丙烯酸和共聚Ñ-异丙基丙烯酰胺。水凝胶的生物降解性，生物相容性和机械性能的特征在于水凝胶对细胞无毒，而与pH 7.4相比，在pH 1.2时显示出可逆的> 80％的体积减少。药物释放曲线显示，在pH值为1.2时，四环素与阿霉素的释放量有所不同，两种药物在pH 7.4时均释放。通过改变交联密度和pH值可以调节生物降解性，在pH 7.4的2周内观察到最佳凝胶的总降解。

更新日期：2017-12-18

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